TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction

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TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction

T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as...

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ژورنال

عنوان ژورنال: BMB Reports

سال: 2016

ISSN: 1976-6696

DOI: 10.5483/bmbrep.2016.49.6.248